Relationship between cholesteryl ester transfer protein and LDL heterogeneity in familial hypercholesterolemia
نویسندگان
چکیده
منابع مشابه
Relationship between cholesteryl ester transfer protein and LDL heterogeneity in familial hypercholesterolemia.
Small, dense LDL particles have been associated with an increased risk of coronary artery disease, and cholesteryl ester transfer protein (CETP) has been suggested to play a role in LDL particle remodeling. We examined the relationship between LDL heterogeneity and plasma CETP mass in familial hypercholesterolemia (FH). LDL particles were characterized by polyacrylamide gradient gel electrophor...
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This study examines the cholesteryl ester transfer protein (CETP)-mediated exchange of cholesteryl linoleate hydroperoxide (Ch18:2-OOH) and cholesteryl linoleate hydroxide (Ch18:2-OH) between low density lipoprotein (LDL) and high density lipoprotein (HDL). When [3H]Ch18:2-OOH- and [3H]18:2-OH-labeled LDL were incubated at 37 degrees C for 0-24 h with unoxidized HDL and purified CETP, Ch18:2-OO...
متن کاملIs cholesteryl ester transfer protein (CETP) deficiency atherogenic in familial hypercholesterolemia.
Atherosclerosis is considered to be caused by many risk factors. Epidemiological studies have shownthat the co-existence of multiple risk factors contributes to the progress in the disease more heavily than a single risk factor. A high level of LDLis a very strong risk factor for coronary heart disease (CHD), showing the high incidence of angina or myocardial infarction in familial hypercholest...
متن کاملPreferential cholesteryl ester acceptors among the LDL subspecies of subjects with familial hypercholesterolemia.
Elevated cholesteryl ester transfer protein-mediated transfer of cholesteryl ester (CE) from high-density lipoprotein (HDL) to low-density lipoprotein (LDL) may contribute to the atherogenicity of LDL in subjects with familial hypercholesterolemia (FH). To identify the major CE acceptors among LDL subspecies, we investigated the qualitative and quantitative features of CE transfer and exchange ...
متن کاملPlasma cholesteryl ester transfer protein.
The plasma lipoproteins are continuously remodeled during their transit through the plasma compartment, owing to the action of lipid metabolizing enzymes and lipid transfer processes. These activities have a major effect on the composition, size, and concentration of the lipoproteins. Lipid transfer processes involving neutral lipids and phospholipids are mediated by specialized plasma proteins...
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ژورنال
عنوان ژورنال: Journal of Lipid Research
سال: 2004
ISSN: 0022-2275
DOI: 10.1194/jlr.m300420-jlr200